Measuring Blood Biomarkers with Greater Sensitivity - Cathepsin B Assay Developed

An ultrasensitive biomarker assay for cathepsin B measurement in blood has been developed as a research tool. Cathepsin B is a lysosomal cysteine protease that is important to a wide variety of functions throughout the body. It is involved in broad spectrum of diseases, injury states, and infections including cancer, dementia, brain trauma, as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Accurate measurement of cathepsin B is often challenging to achieve within blood samples due to interference or “noise”. This newly developed assay for cathepsin B offers increased accuracy and little to no background, which may facilitate research and enhance diagnostic utility of cathepsin B as a blood biomarker.

These studies were originally published in American Chemical Society (ACS), Omega

“Single Molecule Assay for Ultrasensitive Detection of Cathepsin B in Human Blood”

by

Bharani Thangavelu* and Angela M. Boutté

https://pubs.acs.org/doi/10.1021/acsomega.1c00180

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