noun: biomarker; plural noun: biomarkers
a measurable substance in an organism whose presence is indicative of some phenomenon such as disease, infection, or environmental exposure.
"a biomarker that may predict aggressive disease recurrence in liver transplant recipients"
A biomarker is an objective and quantifiable characteristic that is measured as an indicator of a biological process, an exposure, or an intervention. In brain trauma and neurological disease, protein biomarkers derived from brain tissue, cerebral spinal fluid or blood are sought to define mechanisms of injury, disease progression, or therapeutic efficacy. Biomarkers may serve as direct or surrogate measurements of a biological or clinical state. There is a high degree of variance among populations and animal models. Therefore, interpretation of indication, biological function, and relevance of a biomarker (or group of biomarkers) must be carefully evaluated.
With a focus on proteins and protein fragments, Aries Biotech offers insight into the role, function, localization and meaning of neurological biomarkers, the methodologies used, and their application to small animal models as well as clinically relevant studies through:
Strong experience in hypothesis as well as product-driven environments
Ability to interpret and articulate analytical subject matter
Hands-on and didactic experience with biomarker assay development and testing
Extensive background in biochemistry and neuroscience
Strong ability to interpret client needs, develop and articulate solutions, and manage delivery of milestones for the client
Ability to provide insights regarding the fields of neuroscience biomarkers
Excellent written and verbal communication skills for varied audiences (new researchers, conference managers, experienced leaders, and clients with non-scientific backgrounds)
Expertise in biomarker analysis in translational models and human subjects
Assessment of market, analytical, and clinical trends to advise board members
Why Study Biomarkers?
Presence or Absence of Brain Trauma or Disease
Evaluation with Variable Conditions
Direct or Surrogate Evidence of Recovery
Neurotrauma and Neurological Disease
Analysis of Brain Tissues , Cerebral Spinal Fluid, and Blood
Extrapolation of Data from Small Species
Interpretation of Systemic Biomarkers